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In vivo efficacy of mAbs elicited after SpFN vaccination against VoC Delta We next sought to further explore the ACE2 inhibition and breadth of neutralization potency against SARS-CoV-2 VoC and determine if these mAbs could protect against a SARS-CoV-2 VoC viral challenge

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Statistical analysis Using data generated from a pilot study and G*Power 3.1 software (Dsseldorf, Germany), it was determined that a sample size of 15 would provide 80% power to detect an increase in CNS GSH concentrations between pre- and post-administration values, with an accepted alpha value of 0.2