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Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

In its complete response letter (CRL), the regulator said the application could not be approved based on data submitted to date and requested another Phase III study to further assess the safety and efficacy of the treatment, according to Lykos

Collagen And Proteoglycan Abnormalities In The GDF-5-Deficient Mice and Molecular Changes When Treating Disk Cells With Recombinant Growth Factor

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Excessive build-up of LIP is avoided by sequestration of iron, in a bioavailable yet non-toxic form, by ferritin (Harrison and Arosio, 2008