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1484-C PROTEIN EXPRESSION ASSOCIATED WITH ALANINE AMINOTRANSFERASE INCREASE DURING BEPIROVIRSEN TREATMENT: ANALYSIS OF THE B-CLEAR STUDY William Jordan 1 , Jennifer Singh 1 , Shihyun You 1 , Ji Won Cremer 2 , Robert Elston 3 , Jared Delahaye 1 , Johannes Freudenberg 1 , Melanie Paff 1 and Dickens Theodore 2 , (1)GSK, Collegeville, PA, USA, (2)GSK, Durham, NC, USA, (3)GSK, Stevenage, Hertfordshire, UK Background: In the Phase 2b B-Clear study, 300 mg bepirovirsen (BPV

Of these, 2 patients had 100 % necrosis, 3 had 50% obstruction of one or more coronary arteries on angiogram

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It then undergoes a nicotinamide adenine dinucleotide phosphate (NADPH) dependent one-electron reduction to form its free radical, which reacts with molecules to produce superoxide ion

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Shushan A., Ben-Bassat H., Mishani E., Laufer N., Klein B.Y., Rojansky N

doi: 10.1038/s41598-024-82938-y 51