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60 Thakker, D., Raval, A., Patel, I

Furthermore, mitochondrial damage is present early in disease course in TDP-43 A315T mice and increases motor neuron vulnerability (Gautam et al., 2019), consistent with dysregulation of the redox system early in neurodegeneration

Cell 57 , 397407 (2015)

In contrast, this correlation increased significantly when considering only DEPs and their corresponding mRNAs (R = 0.2362)

However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)