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Exposure to cadmium also potentially reduces cerebral blood flow (158) [particularly cortical blood flow (159)], as cadmium has a disruptive effect on angiogenesis (160)

doi: 10.1016/j.sjbs.2023.103779

Elevated heme levels are a hallmark of multiple cancers, reflecting an adaptive rewiring of metabolism rather than a passive accumulation

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These functions are all part of the NEM, neuroendocrine metabolic response

4.1.2 Stabilizing mitochondrial function in neurodegenerative models Loss of mitochondrial membrane potential (MMP), impaired ATP synthesis, and heightened oxidative/nitrosative stress can contribute to neuronal apoptosis and cognitive decline (Finsterer, 2012)