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Tirzepatide (Mounjaro, Zepbound) has the greatest weight loss with clinical results of up to 25% of body weight

Its dual GLP-1 and GIP receptor activation produced a 20.9% average body weight reduction at 72 weeks in the SURMOUNT-1 trial, and more recent SURMOUNT-5 head-to-head data confirmed its superiority over Semaglutide

Providers often mix the product with a local anesthetic or apply a numbing agent to help improve comfort

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