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doi:10.1186/s12906-020-03071-7

ARV-110 and ARV-471 have progressed to phase II clinical trials

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One example, cells in white matter are generally derived from classic Olig-2+ oligodendrocyte progenitor cells (OPC), while grey matter has a higher incidence of NG2+ OPCs (known as NG2 glia) ( Differentiation of OPCs into fully myelinating oligodendrocytes is related to both axonal and glial inducing factors