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According to another study, GA increases liver PON1 (paraoxonase1) and arylesterase activity via the intracellular signaling cascade PPAR-PKA-cAMP

In liver, kidney, and heart transplant patients, serum conversion rates were 37.5, 16.6, and 34.8%, respectively

Signs that mast cell activation might be involved include: symptoms that persist long after pollen exposure ends, reactions to multiple unrelated triggers (foods, stress, exercise, temperature changes, chemicals), digestive symptoms accompanying respiratory ones, symptoms that seem disproportionate to exposure levels, and symptoms that respond poorly to antihistamines alone

Ryu MS, Zhang D, Protchenko O, Shakoury-Elizeh M, Philpott CC

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