glutathione redox imbalance in brain disorders and Aging Neurodegenerative Diseases: Potential Effect of

doi: 10.1016/j.immuni.2019.04.011 95 KoutsakosMWheatleyAKLohLClemensEBSantSNussingSet al

Chae WO, Kim GD

How It Works Natural antioxidant glutathione occurs in the body and is often discussed in relation to cellular balance and the breakdown of certain compounds

Low phenol content usually eliminates the need for anesthesia

Not a guide for human or animal use

The mechanism works as follows: Ergothioneine binds to MPST with high affinity (Kd of 3.2 M) MPST activation increases HS production HS causes persulfidation of glycerol-3-phosphate dehydrogenase (GPDH) Persulfidated GPDH shows enhanced activity for NAD+ regeneration Elevated NAD+ supports muscle vascularization and stem cell health In middle-aged rats, three weeks of ergothioneine supplementation (20 mg/kg) nearly doubled exercise endurance and running distance while increasing muscle mass and NAD+ levels [5]