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By stimulating the Nrf2-ARE pathway, NAC demonstrates neuroprotective effects, enhancing antioxidant capacity and improving proteostasis through the regulation of the ubiquitinproteasome system [19,41]

Maiti A, Rausch CR, Cortes JE, Pemmaraju N, Daver NG, Ravandi F, Garcia-Manero G, Borthakur GM, Naqvi K, Ohanian M, Short NJ, Alvarado Y, Benton CB, Kadia TM, Takahashi K, Yilmaz M, Jain N, Kornblau, SM, Sasaki K, Andreeff M , Bose P, Ferrajoli A, Issa GC, Jabbour E, Masarova L, Rytting ME, Thompson PA, Wang SA, Konoplev S, Chen Z, Goswami M, Maduike R, Guerrero JA, Zhang Q, Cavazos A, Ma H, Bivins CA, Wade A, Adewale SL, Tse S, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Welch JS, Patel KP, Kantarjian HM, Konopleva MY, DiNardo CD

Decreased efficacy was observed when this dose was spread over two administrations (50 mg/kg i.p

Three patterns emerged across testing

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This work was supported by the Bijzonder Onderzoeksfonds under the Grant No