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Variations in complement pathway genes, especially CFH, C3, C2 , and ARMS2/HTRA1 , increase susceptibility to chronic inflammation and drusen formation ( Dry (atrophic) AMD is responsible for 8590% of cases ( This literature survey was undertaken because of the prominent role of oxidative stress in the initiation and progression of both forms of AMD as well as the discovery of melatonin in mitochondria of somatic cells ( in vitro and in vivo models ( 2 Pathology of retinal pigment epithelium during age-related macular degeneration The RPE, a single layer of polarized cells that is situated between the rods and cones and the choriocapillaris in the outermost portion of the retina, undergoes major pathological changes during AMD progression (Figure 1)

10.3390/ph11040121 35 VivancosM.MorenoJ

Liddell, [email protected] This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Both substances function within the bodys antioxidant network, but they also have unique mechanisms of action

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Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, et al