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Gel-shift analysis revealed reduced LXR binding activity in the I148M oe M1 macrophage, leading to the downregulation of ABCA1 (-36.7%) and ABCG1 (-32%)

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In vitro prophylactic injection of IL-22 can significantly reduce the expression of pro-inflammatory factors IL-6, IL-1, TNF-, and the liver necrosis area and increase the expression of hepatocyte proliferation marker Ki-67, suggesting that IL-22 through promoting hepatocyte proliferation mediates hepatoprotective functions and has the therapeutic potential in AILI [174]

Association of HLA Genotypes with Phenobarbital Hypersensitivity in Children

When these breaks arise within repeat-containing regions, the subsequent repair process may result in large deletions via non-allelic homologous recombination [138, 139]

This can lead to a host of health problems, from premature aging to chronic fatigue