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In studies related to non-small cell lung cancer, it has been observed that a reduction in amino acid metabolism, along with the inactivation of the mTOR signaling pathway, can lead to the exhaustion of CD8+ T cells, thereby diminishing the body's immune defense capabilities (91)

On this topic, the search strategy generated three studies eligible for inclusion

In addition, Alphavirus Nsp2 is a 53 helicase that is critical for the synthesis of subgenomic RNA 96

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For instance, IR-induced overexpression of Wnt16B in fibroblasts activates the canonical Wnt signaling pathway and controls the development of regulatory T cells, leading to cancer immune evasion

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