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In nature, ALA is found only in the R form (Figure 1) and is present in the body both in free form and conjugated to conserved lysine residues in an amide bond, thus making this isomer a key cofactor in different biological systems [7]
Due to hierarchical gene regulation at multiple levels in a context-dependent manner, fine-tuning of gene expression is crucial for protein expression and pathway construction
Another study showed that benfotiamine reduces cerebral oxidative stress associated with diabetes in mice
It is possible to delay (and sometimes preventover the course of a normal human lifespan) significant cataract development
