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Summary: Triangular Fibrocartilage Complex (TFCC) tears are a common and painful wrist injury, often leading to surgery and extended recovery times

doi: 10.1126/science.aad3503 48 FanY.PedersenO

However, when methionine deprivation is prolonged, it disrupts protein synthesis, including that of CHAC1, at the translational level

5B), and while nuclear respiratory factor 1 (NRF1), which plays a crucial role in regulating targets in mitochondrial DNA transcription and replication, was highly expressed under hyperglycemic conditions, several key proteins associated with mitochondrial biogenesis and maintenance were significantly reduced

As observed in the IdeS and gasMac-1 crystal structures, these loops are conformationally flexible (Fig