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Curcumin (direct inhibitor of STAT3 and NF-kB activation) 281,282,283 is studied in the combination with PDT and/or PTT/hyperthemia 256,284,285 Curcumin also decreases HSP efficiency in cancer cells 286 (including HSP-70) 256 , effectively suppressing the hypoxic phenotype in tumor tissues and activating the anti-tumor immune system 287,288

(120) found that LRAC increased ROS production by upregulating NADPH oxidase 4 (NOX4) expression, but this increase in ROS further activated NLR family pyrin domain containing 3 (NLRP3) inflammatory vesicles and induced IL-1 and interleukin-18 (IL-18) release, which drives focal death

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As found here, PAT is a noncompetitive TGR inhibitor with a K i value in the low nanomolar range, showing that PAT is by three orders of magnitude a better inhibitor of TGR than of PFK, which has an IC 50 of 16 M [65]