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This function is carried out by a freestanding protein termed ThrRS-ed, a structural homolog to the DTDs mentioned above (Beebe et al

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Ferroptosis can contribute to the manifestations of RILI, with IR inducing mitochondrial shrinkage, iron accumulation, ROS, and lipid peroxidation generation, and expression of ferroptosis-related genes [56, 71, 73]

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E2-2,3 and E2-3,4 quinones adduct to DNA, leading to depurination and the accumulation of mutations during replication [149] as well as random losses or gains of metaphase chromosomes [150]

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