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Although the pathogenetic effects of increased intestinal permeability has been widely discussed in many diseases, their roles in hematologic and oncologic diseases are less examined

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Diabetic Ketoacidosis (DKA) is a serious and potentially fatal acute complication of diabetes mellitusmost commonly seen in Type 1 diabetesresulting from absolute or relative insulin deficiency combined with increased levels of counter-regulatory hormones (glucagon, cortisol, catecholamines, and growth hormone)

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In contrast, idiosyncratic hepatotoxic reactions occur at therapeutic doses in only a small number of individuals in the exposed population

3 Plasticity of pancreatic cells: scRNA-seq evidence in diabetes Alongside the rapidly advancing in vitro approaches, which enable the differentiation of embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) into insulin-producing -cells for subsequent implantation in encapsulated formats (Pagliuca et al., 2014