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A.LeverM.GeorgeP

10.1001/jamaophthalmol.2013.6636 JAMA Ophthalmol

4.4 Sleep disruption including jet lag, shiftwork, and sleep apnea contribute to impaired metabolism Shift work, where an individuals schedule overlaps with their typical sleep time, is linked to various health issues and contributes to the development of shift work disorder in approximately 25% of affected individuals

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: a randomized trial Chen J., et al