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10.1038/s44318-024-00117-1 EMBO J

Gamma-glutamyl cycle and enzyme deficiencies (highlighted in red) related to different diseases (highlighted in blue)

The classification reflects WADA's position that growth hormone fragments fall under the broader category of GH analogs regardless of whether they engage the classical hGH receptor

However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)

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