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Description

Some assay formats also carry risk of misleading readouts when compounds interact with reporters, dyes, membranes, plastics, or plate surfaces, creating signals that appear pathway related but are driven by assay chemistry

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Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA (2009) Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

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Organizations like the Open Medicine Foundation the Solve ME Initiative and Invest in ME - are a few of the perennial heavy hitters

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doi: 10.3389/fmed.2021.648259 53 GovindarajuluM.PinkyP

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When one pathway saturates during hard efforts, the other keeps NO levels elevated

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CCL-11 or Eotaxin-1: an immune marker for ageing and accelerated ageing in neuro-psychiatric disorders

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