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Lead tolerance and accumulation in Hirschfeldia incana , a Mediterranean Brassicaceae from metalliferous mine spoils

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Simultaneously, anti-inflammatory cytokines such as TGF-, GDF-5, GDF-6, IL-4, and IL-10 are also present in the degenerative environment and can, to some extent, delay degeneration and alleviate pain (Wang et al., 2016), with their balance potentially closely related to the polarization state of macrophages (Yamamoto et al., 2022

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This protective effect was evidenced by a reduction in cell death and decreased lactate dehydrogenase (LDH) leakage into the culture medium