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Acknowledgements This work was supported by the National Key R&D Program of China (2020YFA0803200 and 2024ZD0533203), the NSFC-RGC Joint Research Scheme (82361168638 and N_CUHK448/23), the National Natural Science Foundation of China (82573553, 82372613, 22507114, 82360502 and 82222052), Shanghai Municipal Science and Technology (2023SHZDZX02A11), Science and Technology Commission of Shanghai Municipality (23ZR1480400 and 23YF1432900), Fund of Fudan University and Caoejiang Basic Research (24FCB05), Academician Expert Workstation of Yunnan Province (202505AF350068), Basic Research Major Project of Kunming Medical University (202401AY070001-050), First-Class Discipline Team of Kunming Medical University (2024XKTDPY04), Talent Support Program of Yunnan Province (RLMY20250004)

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