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Figure 1: Simplified diagram of ROS production and scavenging: a, Triplet ground-state oxygen 3 O 2 is photo-sensitised (hv + PS) to highly reactive singlet oxygen 1 O 2

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As illustrated in Figure 1, this integrated strategy demonstrates multi-target synergistic effects, significantly improving clinical response, endoscopic remission, and mucosal healing rates, while exhibiting a unique efficacy enhancement and toxicity reduction profile

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