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A therapy including enemas improved the symptoms in 2 studies, but they lacked controls and included only 13 people [68, 69]

Melatonin injections (10 mg/kg) prior to acetaminophen overdose may be more effective than rescue doses for reducing liver toxicity (Kanno 2006), although rescue treatments at this same dose have been shown to effectively protect kidney tissue from cell death (Ilbey 2009)