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once every 3 weeks for 3 months) solution is well tolerated in rats at doses up to 200 mg/kg with no life-threatening toxicity, and the STD 10 is greater than 200 mg/kg [2]

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10 In instances where thiopurine therapy is not tolerated, is contraindicated or, increasingly, is not preferred because of its increased risk of infections and certain malignancies, the use of advanced therapies for ongoing maintenance therapy following steroid induction is indicated