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evidence for skin and hair is largely indirect (via correcting deficiency)

NAD(+)/NADH homeostasis affects metabolic adaptation to hypoxia and secondary metabolite production in filamentous fungi

de la Fuente Revenga M, Zhu B, Guevara CA, Naler LB, Saunders JM, Zhou Z, et al

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Similarly, in neuron-related studies, pharmacologically activating NCLX (using the phosphodiesterase 2 inhibitor Bay 60-7550) to enhance calcium efflux can protect neurons from excitotoxic injury and improve learning and memory in mice [54]

The significant connection between vitamin B5 and energy metabolism implies its potential to influence the pathophysiological processes of LLD by enhancing mitochondrial health and boosting energy production