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Elimination of senescence in these old adult livers by AP20187 reduced number of neutrophils as revealed by IHC for myeloperoxidase (MPO), attenuated fat accumulation in Oil red staining, and decreased levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in sera compared to age-matched vehicle-treated controls, indicating that senescence clearance reduced ethanol-induced injury in aging livers

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

PMID 18511946

The SE, SP, PPV, and NPV of the optimal cutoff values (8.8 kPa) were 70.27%, 76.25%, 28.9%, and 94.9%, respectively

The positive control was 100 M TBHP solution

doi:10.1111/cen.14801