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Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 46 (9), 1133-1142

The apparent overlap in redox potentials could suggest that the cytosolic glutathione and NADP redox couples are able to rapidly equilibrate with each other, for example by the action of glutathione reductase

The peptides effects on enteric neurons, glial cells, and gut barrier integrity suggest multiple pathways through which healing the gut could protect the brain

First, pathway complexity raises on- and off-target risks when modulating ASC, caspase-1, GSDMD, IL-1, NF-B, P2X7R, IKK, FTH1, ACSL4, miR-204, or GPX4, and microglia-specific target engagement is difficult to confirm