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High doses of either form may cause liver dysfunction with long-term use

Front Immunol 9:2134 Krejcik J, Casneuf T, Nijhof IS, Verbist B, Bald J, Plesner T et al (2016) Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

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As it is used to make up for necessary nutrient deficiencies, it is unlikely to have any negative long-term impacts

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