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Description

Pei G, Zeng R, Han M, et al

3.4.2 Induction of apoptosis and inhibition of cancer cell proliferation Both -sitosterol and berberine inhibit cancer cell proliferation by inducing apoptosis through the mitochondria-mediated intrinsic pathway and blocking cell cycle progression (83)

Free Radical Res Commun (1991) 12-13 Pt 1:1315

During this phase: Your invention gets an international filing date An International Search Report (ISR) is issued A written opinion assesses patentability This phase helps you understand the strength of your invention before spending heavily on national filings

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While the accumulation of -syn aggregates and mitochondrial dysfunction have long been established as central features of PD pathology, increasing evidence implicates mtDNA as a potent DAMP that links mitochondrial dysfunction to innate immune activation [161]