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Staging and surgery of esophageal carcinoma, Chap 25

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identified the novel compound called NPD4928 as an FSP1 inhibitor

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Over-activation of iron autophagy results in excessive intracellular iron deposition, causing glutathione peroxidase 4 (GPX4) levels to fall and GSH to become diminished, which finally causes cell membrane structures to collapse and rupture and iron death