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It is a 43-amino-acid peptide that supports cellular migration, wound healing, and tissue regeneration

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Activation of the BDNF pathway is well-known to increase dendritic spine growth and axonal connectivity, both of which are crucial mechanistic underpinnings of learning

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Histological analysis showed that FOXO4-DRI treatment improved the testicular microenvironment, leading to thicker seminiferous epithelia, increased spermatogenic cells, and more mature spermatozoa in the central lumen

After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10