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Here, we accounted for the N-glycosylation sites in different conformations on the SARS-CoV-2 trimeric S-protein in order to identify promising antibody accessible epitopes

TMA syndromes require rapid intervention with plasmapheresis, immunosuppressive agents (corticosteroids), or complement-inhibiting therapies (e.g., eculizumab) due to their natural pathophysiology of endothelial damage and complement dysregulation

, 15 , 578-584, Rosen, H., and Klebanoff, S

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Zhu Y, Lin G, Dai Z, Zhou T, Li T, Yuan T, Wu Z, Wu G, Wang J

After removal of cellular proteins in the supernatant, this precipitant is then solubilized in low-salt reducing buffer, reversing the phase transition and inducing C-terminal cleavage of the intein