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Transfusion threshold generally Hgb 60 or prior thrombosis): cytoreductive therapy with hydroxyurea (first-line) or interferon-alpha (preferred in younger patients, pregnant women, or hydroxyurea intolerance)

Recognizing External Concerns and Self-Reflection: Awareness of AUD can arise through external concerns voiced by friends, family, or colleagues

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Gently rotate the vial between your fingers with a slow swirling motion

This was fully investigated in 1849, by British physician Thomas Addison, from which it acquired the common name of Addison's anemia