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doi:10.1016/j.heliyon.2021.e08281 2

However, in preclinical models and GBM patients, systemic chemotherapy, including TMZ, has an inherent immunosuppressive effect, which allows the already minimal number of T cells in TME to rapidly deplete or develop tolerance to tumor antigens, leading to a possible failure of immunotherapy to promote TILs effector function [532]