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Secondly, accurately detecting nROS currently poses significant challenges owing to the difficulties associated with fluorescent probes crossing the nuclear membrane and avoiding DNA damage response (DDR) pathways

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Moreover, the increase in UV radiation on earth due to stratospheric depletion remains a major environmental threat to the human organism, increasing its risk of damage due to oxidative stress 6

Thus, a direct correlation between O -GlcNAc and cell nutrient composition exist, allowing O -GlcNAc to correlate with many pathologic phenotypes associated with various diseases including DR