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All three metabolites are redox-active molecules and, as such, the levels of each may alter to maintain cellular redox homeostasis

Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy: Replication of the Reported Candidate Susceptibility Loci

Adequate stomach acid is required to release the vitamin from the protein, and a substance called intrinsic factor is necessary to ensure its absorption

This also supports the functional role of these enzymes in H 2 O 2 -scavenging, thereby implicating their importance in the plant defense

Dizocilpine reduces cGMP levels in the cerebellum, but does not affect the cerebral cortex and hippocampus, while L-NAME and 7-NI reduce cGMP levels in the cerebral cortex and hippocampus (Yamada et al., 1996)

Furthermore, when BBB integrity disruption was assessed by dynamic contrast, enhanced MRI revealed BBB heterogeneity in patients with BM [173]