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Previous studies in myocardial ischemia have revealed that ischemia leads to a progressive loss of cholesterol from tissues and the sarcoplasmic and sarcoplasmic reticulum, accompanied by a significant increase in mitochondrial cholesterol content that is admixed explicitly to this membrane system [63]

The identification of driver mutations (such as EGFR and HER2) and antigen expression profiles (such as TROP2 and Claudin18.2) through comprehensive pan-cancer genomic analysis (e.g., the PCAWG project) can enhance target selection and predict treatment outcomes ( However, the path to personalized ADC therapy is still fraught with challenges