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93 used low concentrations of the ALK4/5/7 kinase inhibitor SB-505124 to maintain TGF--induced Smad2/3 signaling, which is crucial for cartilage homeostasis, while blocking the harmful Smad1/5/9 pathway that contributes to chondrocyte hypertrophy and OA progression, as evidenced by decreased expression of Runx2 and Col10a1

However, relying on a few indicators of ferroptosis to prove the anti-ferroptosis effect of DHT is far from sufficient

eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation

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Furthermore, Vitamin D plays a foundational role in maintaining gut microbiota homeostasis and intestinal barrier integrity