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Although the disease begins with autoimmune attacks on the myelin sheath of the CNS, the chronic inflammatory environment directly leads to progressive neurodegeneration, including axonal disruption, neuronal loss, and brain atrophy

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10.1016/j.jddst.2023.105209 128 MaZ.LiN.ZhangB.HuiY.ZhangY.LuP.et al (2020)

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If conservative and regenerative options fail, surgical repair may be consideredespecially in cases of full-thickness tears or functional decline

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Furthermore, a clinical study showed that vanin-1 (VNN1) and matrix metalloproteinase 9 (MMP9) in the peripheral blood differentiated PDAC-associated diabetes from T2D with an AUC of 0.95, sensitivity of 95.83 and specificity of 76% ( Table 1 ) ( Figure 4C ) (107)

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An operational definition of epigenetics

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