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Research applications span oxidative stress investigation, detoxification mechanism studies, immune system modulation, neuroprotection pathways, hepatic function, and age-related research

A recent study engineered a nanopyroptosis amplifier that contained lonidamine (LND) and black phosphorus nanosheets (BP) for the treatment of glioblastoma (GBM), and BP was used to block mitophagy flux and amplify LND-induced pyroptosis [94]

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This process thereby downregulates the NF-B pathway, augments Treg differentiation, and suppresses Th17 expansion and inflammatory cytokine release (215, 216)

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