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doi:10.1038/nature08299

In this case, despite markedly low vitamin B12 levels and deep sensory impairment, there were no findings of anemia, upper motor neuron signs (such as hyperreflexia or a positive Babinski sign), or abnormal signal intensities in the posterior columns of the cervical spinal cord on MRI [7]

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Oral dosing ranges discussed in research community use Phase Weeks 12 (start low) Daily dose 50 mg once daily Notes Morning dosing is the pattern most often reported

Incorrect strength assumptions may cause inaccurate dosing risks

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