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Mast cells are ubiquitous throughout the body, situated at the interfaces between our internal tissues and the external environment, such as the skin, respiratory tract, and gastrointestinal lining

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4.4 Lignans In terms of anti-inflammatory effects, flax linoorbitides (LOBs) and enterolactone (ENL) downregulate TNF- and upregulate PPAR- expression to inhibit inflammatory signaling (Plaha et al., 2022)

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Therefore, there is growing interest in studying the delivery of neuroprotective agents to enable drugs to cross the BBB and reach their target sites in the brain parenchyma