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Biochim Biophys Acta

This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

The compounds research profile now spans adipose tissue biology, skeletal muscle physiology, gut microbiome modulation, cardiovascular metabolic pathways, and cancer cell biology

Likewise, autoimmune conditions that affect the stomach lining, such as atrophic gastritis or pernicious anemia, directly impact intrinsic factora protein essential for B12 absorption