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The results pointed out that metformin treatment for more than 4 years can significantly reduce the risk of PD (HR 0.19, 95% CI 0.120.31) [155]

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It's time to replace the term "heavy metals" with "potentially toxic elements" when reporting environmental research

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Tat 72 lacks the 73 RGD 75 motif that permits transmigration across the blood brain barrier (93), potentially limiting its dissemination to the CNS in vivo

However, increased ROS production in PD is closely linked to mitochondrial dysfunction (Weng et al., 2018) The discovery that mutations in the genes encoding proteins like -syn, parkin, DJ-1, or PINK are associated with familial types of PD raises the question of how oxidative stress and dopamine (DA) cell damage are related to mitochondrial dysfunction (Gonchar et al., 2019