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Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellmans reagent

In AD patients, decreased BDNF indicates a lack of trophic support and accelerates neurodegeneration 42 Generally, AD is linked to deteriorated oxidative state of brain tissue, which is reflected in levels of anti-oxidant enzymes such as GSH, and SOD and pro-oxidant markers such as MDA plays a significant role in the progression of neurodegenerative disorders 38,45,46

Elevated UA levels promote a pro-oxidative and pro-inflammatory state with both conditions playing a crucial role in the pathophysiology and development of CVD

GSH is also involved in the neutralization of lipid aldehydes (4-HNE, MDA) generated by mitochondrial lipid peroxidation

Advice: Food supplements must not be used as a substitute for a varied and balanced diet and a healthy lifestyle