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However, unlike FANCJ, which can efficiently resolve unimolecular (G4) G-quadruplexes (Wu and Spies, 2016), DDX11 efficiently unwinds two stranded anti-parallel (G2) G-quadruplexes to a much greater extent than G4 structures (Wu et al., 2012)

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Histological analysis confirmed a marked reduction in the inflammatory cell count and greater collagen deposition at the wound site, indicating a higher degree of tissue regeneration than in the control group

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The association between mitochondrial activity and low sensitivity to anthracyclines, Ara-C, and Venetoclax has been documented in cell lines and primary leukemia cells and confirmed using in vivo models (Figure 2)