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61 demonstrated that NR supplementation altered the gut microbiome in mice and demonstrated that the gut microbiome change was able to impact weight gain in mice fed a high-fat diet

Adverse reactions following intramuscular (IM) injection have included anxiety, mild transient diarrhea, ataxia, nervousness, pruritus, transitory exanthema, and a feeling of swelling of the entire body

Theoretically, chronic lipolysis activation could deplete essential lipid stores or disrupt adipose tissue-derived signaling pathways (via adipokines), though this remains speculative

Those who have had bariatric surgery or have malabsorption issues might need special dosing plans

[DOI] [PMC free article] [PubMed] [Google Scholar] 347.Yang, L