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In addition, a systematic review of the first 39 pages (3,900 entries) of IBD trials registered on ClinicalTrials.gov identified 127 active studies with antioxidant/ROS as the primary endpoint (Table 1)

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Neuronal autophagic deficits have been implicated in PD, with SNpc samples showing that PD neurons have increased autophagic degeneration including vacuolation of the endoplasmic reticulum and increased lysosome-like vacuoles [134]

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The researchers followed 17 patients over a one-year period, tracking their pain levels and improvement after treatment